Search results for "Factor D"
showing 10 items of 48 documents
Recombinant factor VIII: past, present and future of treatment of hemophilia A.
2018
The development of recombinant factor VIII (rFVIII) was initially driven by the necessity to treat hemophilia A (HA) patients with FVIII concentrates without the risk of transmitting infectious agents. Over the last three decades the safety of rFVIII has been further improved by completely removing animal or human proteins from the manufacturing process, so that patients would not be exposed to known or emerging pathogens. Recent efforts have concentrated on improving the expression of rFVIII, reducing its immunogenicity and enhancing its pharmacokinetic (PK) behavior. These new goals have been possible thanks to the develop-ment of biotechnology and a better knowledge of the function and s…
Expression Profile of VEGF-C, VEGF-D, and VEGFR-3 in Different Grades of Endometrial Cancer
2019
Background:Vascular endothelial growth factor (VEGF)-C, -D, and VEGF receptor-3 are proteins characterized as crucial for tumor lymphangiogenesis. It is accompanied by angiogenesis during wound healing, but also in the neoplastic process. The research studies have shown that the lymphatic system plays a key role in the progression of carcinogenesis.Objective:The aim of this study was to evaluate changes in the expression of VEGF-C, VEGF-D and VEGFR-3 in different grades of endometrial cancer (G1-G3).Methods:The study included 45 patients diagnosed with endometrial cancer (G1=17; G2=15; G3=13) and 15 patients without neoplastic changes. The expression of VEGF-C, VEGF-D, and VEGFR-3 was asses…
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
2019
Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic data, but efforts on analyzing single-cell epigenomic data and on trajectory visualization remain limited. Here we present STREAM, an interactive pipeline capable of disentangling and visualizing complex branching trajectories from both single-cell transcriptomic and epigenomic data. We have tested STREAM on several synthetic and real datasets generated with different single-cell techno…
Indicadores de calidad de las publicaciones científicas en psicología jurídica
2017
[ES]: Las publicaciones científicas son una de las dimensiones básicas de la evaluación de la calidad de la investigación del personal docente e investigador en España. El criterio más utilizado para la evaluación es la publicación de trabajos en revistas incluidas en las bases de datos de la Web of Science (WoS) o Scopus. El objetivo de este trabajo es conocer que revistas de psicología, que publican trabajos de psicología jurídica, son las que están actualmente incluidas en las bases de datos Web of Science (WoS) y Scopus, ofrecer un análisis y comparación de los indicadores de calidad de las revistas en estas bases de datos, con el propósito de que los investigadores que trabajan en esta…
Consumo de alcohol, tabaco, cannabis y otras drogas en la adolescencia: efectos de la familia y peligro del barrio
2015
El objetivo de este estudio fue analizar los factores de protección o riesgo de los estilos educativos parentales para el consumo de alcohol, tabaco, cannabis y otras drogas, considerando la interacción de los estilos parentales con la peligrosidad del barrio. A partir de las respuestas de 628 adolescentes, 369 mujeres (58.8%) y 259 hombres (41.2%) entre 15 y 17 años (M = 16.03 años, DT = 0.79 años), se clasificaron las familias según el estilo educativo (autorizativo, indulgente, autoritario o negligente) y el riesgo percibido en el barrio (alto o bajo). Los resultados no mostraron interacciones, pero sí efectos principales de los estilos educativos y del riesgo percibido. Los adolescentes…
Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases
2005
✓ Chronic subdural hematomas (SDHs) generally occur in elderly patients. Its pathogenesis is usually related to head trauma with tearing and rupture of the bridging veins, although in some cases a history of trauma is not recognizable. There are many reports regarding the association between spontaneous chronic SDHs and an alteration in coagulative parameters. A coagulative disorder should be suspected when an unexplained hemorrhage occurs, especially in a young patient. The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs. The role of FXIII in the pathogenesis of chronic SDH is emphasized. In patients with unexpla…
VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab
2008
AIM: To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS: The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines an…
Dissemination and national and international impact factors of spanish journals
2008
El artículo ofrece un estudio sobre las revistas científicas españolas vigentes. Se analizan datos sobre la antigüedad de las publicaciones, soporte documental, periodicidad, idiomas, difusión y visibilidad nacional e internacional. El propósito del trabajo ha sido realizar un análisis bibliométrico de las revistas científicas españolas que se editan actualmente. Se ha procedido a la consulta de diferentes directorios, repertorios y bases de datos bibliográficas. Se ha comprobado la veracidad de los datos recogidos consultando las páginas web de las revistas y a través del contacto con los editores de las publicaciones. Los resultados muestran que el comportamiento es desigual entre las rev…
Effects of acute exercise, exercise training, and diabetes on the expression of lymphangiogenic growth factors and lymphatic vessels in skeletal musc…
2007
Blood and lymphatic vessels together form the circulatory system, allowing the passage of fluids and molecules within the body. Recently we showed that lymphatic capillaries are also found in the capillary bed of skeletal muscle. Exercise is known to induce angiogenesis in skeletal muscle, but it is not known whether exercise has effects on lymphangiogenesis or lymphangiogenic growth factors. We studied lymphatic vessel density and expression of the main lymphangiogenic growth factors VEGF-C and VEGF-D and their receptor VEGFR-3 in response to acute running exercise and endurance exercise training in the skeletal muscle of healthy and diabetic mice. VEGF-C mRNA expression increased after t…
The Properdin System: Composition and Function
1978
. This article summarizes the physicochemical data on the factors which compose the properdin system in guinea pig and man. The following other topics are discussed: (1) Activation of the properdin system; (2) Formation of the initiating and amplification C3 convertases; (3) Formation of the C5 convertase, and (4) Regulatory control mechanisms of the properdin system.